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Etacrynic acid
CAS No. 58-54-8
Etacrynic acid ( Edecrin )
产品货号. M15149 CAS No. 58-54-8
一种用于治疗高血压和肿胀的袢利尿剂，一种新型配体和 MAP2K6 激酶抑制剂，可部分通过非保守半胱氨酸残基的烷基化来抑制 MAP2K6。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 25MG | ￥251 | 有现货 |
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| 50MG | ￥373 | 有现货 |
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| 100MG | ￥632 | 有现货 |
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| 200MG | 获取报价 | 有现货 |
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| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Etacrynic acid
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述一种用于治疗高血压和肿胀的袢利尿剂，一种新型配体和 MAP2K6 激酶抑制剂，可部分通过非保守半胱氨酸残基的烷基化来抑制 MAP2K6。
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产品描述A loop diuretic used to treat high blood pressure and the swelling, a novel ligand and inhibitor of MAP2K6 kinase that inhibits MAP2K6 in part through alkylation of a nonconserved cysteine residue; shows anticancer activity, and also is a potent inhibitor of glutathione S-transferase; shows antitumor effects and may enhance the cytotoxicity of chemotherapeutic agents by binding to glutathione and inhibiting WNT signaling.Other Indication Phase 2 Clinical.
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体外实验——
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体内实验——
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同义词Edecrin
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通路MAPK/ERK Signaling
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靶点MEK
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受体NKCC2|GST
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研究领域Other Indications
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适应症Other Disease
化学信息
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CAS Number58-54-8
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分子量303.135
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分子式C13H12Cl2O4
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纯度>98% (HPLC)
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溶解度Ethanol: 30 mg/mL; DMSO: 30 mg/mL （ < 1 mg/ml refers to the product slightly soluble or insoluble )
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SMILESCCC(=C)C(=O)C1=C(C(=C(C=C1)OCC(=O)O)Cl)Cl
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化学全称Acetic acid, [2,3-dichloro-4-(2-methylene-1-oxobutyl)phenoxy]- (9CI)
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Chan AI, et al. J Am Chem Soc. 2017 Aug 2;139(30):10192-10195.
2. Wang R, et al. Clin Cancer Res. 2012 Dec 15;18(24):6690-701.
3. Bryant ZE, et al. Bioorg Med Chem Lett. 2011 Feb 1;21(3):912-5.
4. Liu B, et al. Oncotarget. 2016 Sep 6;7(36):58038-58050.
